The Restylane family of products includes Restylane, Restylane-L®, Perlane®, and Perlane-L®. These products can be used individually to add volume and fullness to the skin to correct moderate to severe facial wrinkles and folds, such as the lines from your nose to the corners of your mouth (nasolabial folds or laugh lines); lipstick lines (the area just below the nose and above the upper lip); the corners of the mouth; and marionette lines (the area that extends downward from the corners of the mouth to the jawline).


The safety and effectiveness of products in the Restylane family for the treatment of anatomic regions other than nasolabial folds have not been established in controlled clinical studies. Patients should be limited to 6.0 mL per treatment.

How often should I be treated?

Restylane injectable gel has been clinically proven to provide results that last up to 18 months, with only one follow-up treatment at either 4.5 or nine months. Your healthcare professional can work with you to help you establish your Restylane Regimen. Perlane injectable gel results may last up to six months after a single treatment.

When will I see results?

The Restylane family of products instantly add volume to help restore youthful contours, so you’ll see results immediately following your treatment.

How much Restylane injectable gel will I need for full correction?

Due to the individual needs of each patient, it is important to discuss your full correction with your healthcare professional. However, in a clinical study where patients received full correction for their nasolabial folds (lines from the nose to the corners of the mouth) during initial treatment in the Restylane Regimen, the average volume was 2 to 3 mL per patient.